Journal article
Disrupted axonal fiber connectivity in schizophrenia
A Zalesky, A Fornito, ML Seal, L Cocchi, CF Westin, ET Bullmore, GF Egan, C Pantelis
Biological Psychiatry | Published : 2011
Abstract
Background Schizophrenia is believed to result from abnormal functional integration of neural processes thought to arise from aberrant brain connectivity. However, evidence for anatomical dysconnectivity has been equivocal, and few studies have examined axonal fiber connectivity in schizophrenia at the level of whole-brain networks. Methods Cortico-cortical anatomical connectivity at the scale of axonal fiber bundles was modeled as a network. Eighty-two network nodes demarcated functionally specific cortical regions. Sixty-four direction diffusion tensor-imaging coupled with whole-brain tractography was performed to map the architecture via which network nodes were interconnected in each of ..
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Grants
Awarded by Sylvia and Charles Viertel Charitable Foundation
Funding Acknowledgements
This study was supported by the Australian Schizophrenia Research Bank, which is supported by the National Health and Medical Research Council (NHMRC) of Australia, the Pratt Foundation, Ramsay Health Care, the Viertel Charitable Foundation, and the Schizophrenia Research Institute. The computing resources used to undertake this study were provided by the Florey Neuroscience Institutes and the Department of Electrical and Electronic Engineering at the University of Melbourne. Software development was supported by a Human Brain Project grant from the National Institute of Biomedical Imaging and Bioengineering and the National Institute of Mental Health. Graph measures reported in this article were computed with the MatlabBGL package written by D. Gleich. The author AZ is supported by the Australian Research Council (ID: DP0986320). The author AF is supported by an NHMRC CJ Martin Fellowship (ID:454797). The author MLS is supported by a Ronald Phillip Griffith Fellowship. The author LC is supported by the Swiss Academy of Medical Science and the Swiss National Science Foundation (ID: PASMP3 129357/1). The author CP is supported by an NHMRC Senior Principal Research Fellowship (ID: 628386). The author CFW is supported by National Institutes of Health (NIH) grants: Novel DT-MRI Analyses of White Matter in Schizophrenia (ID: NIH R01MH074794) and Neuroimage Analysis Center (ID: NIH P41RR013218). The author EB is a half-time employee of GlaxoSmithKline. All other authors reported no biomedical financial interests or potential conflicts of interest.